Role of platelet activation in the cardiovascular complications associated with HIV infection: differential effect of abacavir versus tenofovir
نویسندگان
چکیده
Purpose Abacavir use has been associated with an increased risk of ischemic cardiovascular events in several cohort studies, but the pathogenic mechanisms are still unknown. Recently Martinez et al. observed no differences in markers of inflammation, endothelial dysfunction, insulin resistance or hypercoagulability in HIV infected persons treated with either abacavir or tenofovir. While several studies have shown endothelial dysfunction in HIVinfected patients, only a few data are available on the involvement of platelets. Aim of our study was to evaluate markers of platelet activation and endothelial dysfunction in HIV infection comparing patients treated with abacavir or tenofovir.
منابع مشابه
Controversy about abacavir and tenofovir
In general, the risk of complications such as heart attack, stroke and poor blood circulation increases as people age. Among HIV-positive people, the risk of these complications is heightened compared to HIV-negative people because of the long-term effects of HIV infection. Chronic viral infections can cause inflammation, and ongoing inflammation can affect the health of many organ-systems, inc...
متن کاملControversy about abacavir and tenofovir
In general, the risk of complications such as heart attack, stroke and poor blood circulation increases as people age. Among HIV-positive people, the risk of these complications is heightened compared to HIV-negative people because of the long-term effects of HIV infection. Chronic viral infections can cause inflammation, and ongoing inflammation can affect the health of many organ-systems, inc...
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Abacavir (ABC) has been associated with ischaemic cardiovascular events in HIV-infected patients, but the pathogenic mechanisms are unknown. Aim of our study was to assess whether ABC induces in vivo platelet activation and ex vivo platelet hyper-reactivity. In a retrospective, case-control study, in vivo platelet activation markers were measured in 69 HIV-infected patients, before starting the...
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